| http://purl.uniprot.org/citations/26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26991731 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the exact etiology and pathogenesis of Alzheimer's disease (AD) are still unclear, amyloid-β (Aβ) generated by the proteolytic processing of amyloid-β precursor protein (APP) aggregate to form toxic amyloid species. Kinesin-1 is the first identified ATP-dependent axonal transport motor protein that has been proven to affect Aβ generation and deposition. In this paper, we applied dual-color fluorescence cross-correlation spectroscopy (DC-FCCS) to investigate the direct interaction of Aβ with kinesin-1 at the single-molecule fluorescence level in vitro. The results showed that two kinds of enhanced green fluorescent protein (EGFP)-tagged kinesin light-chain subunits of kinesin-1(KLCs), KLC-E and E-KLC inhibited the aggregation of Aβ over a period of time, providing additional insight into the mechanism of axonal transport deficits in AD."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12137"xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Jiao Y."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Hong T."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/author | "Tian S."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/pages | "1028-1037"xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/title | "Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy."xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://purl.uniprot.org/core/volume | "590"xsd:string |
| http://purl.uniprot.org/citations/26991731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/26991731 |
| http://purl.uniprot.org/citations/26991731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/26991731 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |
| http://purl.uniprot.org/uniprot/#_A0A8F9R5D5-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |
| http://purl.uniprot.org/uniprot/#_A0A140VJC8-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |
| http://purl.uniprot.org/uniprot/#_A0A218KGR2-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |
| http://purl.uniprot.org/uniprot/#_B4DGD0-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |
| http://purl.uniprot.org/uniprot/#_A8K048-mappedCitation-26991731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/26991731 |