| http://purl.uniprot.org/citations/26993613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26993613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26993613 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factors (IRFs) are a family of transcription factors that mediate the transcriptional regulation of interferon (IFN) genes and IFN-inducible genes. In this study, IRF-1 gene is cloned from the common carp, Cyprinus carpio L., named CcIRF-1. The full-length cDNA of CcIRF-1 is 1427 bp, including an open reading frame of 861 bp encoding a protein of 286 amino acids. The putative CcIRF-1 is characterized by a conserved DNA-binding domain and includes a signature of six conserved tryptophan residues. The genomic sequence of CcIRF-1 is described, which consists of 9 exons and 8 introns. The sequence analysis shows that CcIRF-1 is clustered into IRF-1 subfamily, and has the closest relationship with the zebrafish IRF-1. CcIRF-1 is found constitutively expressed in different organs of healthy common carp. The main findings are that CcIRF-1 is up-regulated following stimulation with poly(I:C) in all tested tissues. Moreover, the downstream gene of IRF-1 - IFN is found to be correlated with the up-regulation of IRF-1 after injection with poly(I:C). Furthermore, we also isolate the peripheral blood leukocytes (PBLs) and find that there is a relevance between the expression profile of CcIRF-1 and IFN in poly(I:C) stimulated PBLs."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.fsi.2016.03.019"xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Shan S."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Shan S."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Qi C."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "Qi C."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "An L."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/author | "An L."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/name | "Fish Shellfish Immunol."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/name | "Fish Shellfish Immunol"xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/pages | "94-102"xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/pages | "94-102"xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/title | "Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/title | "Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense."xsd:string |
| http://purl.uniprot.org/citations/26993613 | http://purl.uniprot.org/core/volume | "52"xsd:string |