| http://purl.uniprot.org/citations/26997484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26997484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/26997484 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Kv3.3 potassium channel (KCNC3) cause cerebellar neurodegeneration and impair auditory processing. The cytoplasmic C terminus of Kv3.3 contains a proline-rich domain conserved in proteins that activate actin nucleation through Arp2/3. We found that Kv3.3 recruits Arp2/3 to the plasma membrane, resulting in formation of a relatively stable cortical actin filament network resistant to cytochalasin D that inhibits fast barbed end actin assembly. These Kv3.3-associated actin structures are required to prevent very rapid N-type channel inactivation during short depolarizations of the plasma membrane. The effects of Kv3.3 on the actin cytoskeleton are mediated by the binding of the cytoplasmic C terminus of Kv3.3 to Hax-1, an anti-apoptotic protein that regulates actin nucleation through Arp2/3. A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane, resulting in growth cones with deficient actin veils in stem cell-derived neurons."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.02.009"xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.02.009"xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Zhang X.F."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Zhang X.F."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Brown M.R."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Brown M.R."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Desai R."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Desai R."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Horvath T.L."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Horvath T.L."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Kaczmarek L.K."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Kaczmarek L.K."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Hyland C."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Hyland C."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Vaccarino F.M."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Vaccarino F.M."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Navaratnam D."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Navaratnam D."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Gazula V.R."xsd:string |
| http://purl.uniprot.org/citations/26997484 | http://purl.uniprot.org/core/author | "Gazula V.R."xsd:string |