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http://purl.uniprot.org/citations/27000222http://www.w3.org/2000/01/rdf-schema#comment"

Background

Nucleotide oligomerization domain (NOD) proteins are cytosolic pattern recognition receptors that respond to bacterial substrate and induce NF-κB activation in host. Association of NOD polymorphisms have been studied in many autoimmune disorders, however its role in Guillain-Barré syndrome (GBS) remains unknown. We have investigated NOD1 Glu266Lys and NOD2 (Arg702Trp and Gly908Arg) gene polymorphisms among patients with GBS.

Materials and method

Polymorphisms in NOD-1 (Glu266Lys) and NOD-2 (Arg702Trp and Gly908Arg) genes were studied using polymerase chain reaction-restriction fragment length polymorphism in 105 patients with GBS and 100 healthy controls.

Results

Homozygous genotype (Lys/Lys) of NOD1 was significantly associated with GBS (p=0.013); and its subtypes viz. acute motor axonal neuropathy (AMAN) and acute inflammatory demyelinating polyneuropathy (AIDP) (p=0.008 and p=0.024 respectively) than controls. In NOD2 (Arg702Trp and Gly908Arg) polymorphisms, only heterozygous genotype (Arg/Trp and Gly/Arg) showed significant association with GBS (p=0.001 and p=0.01 respectively); subtypes AMAN, acute motor-sensory axonal neuropathy (AMSAN) and AIDP showed association with heterozygote Arg702Trp (p=0.001; p=0.029 and p=0.001 respectively) whereas only AIDP was associated with heterozygote genotype Gly908Arg (p=0.003).

Conclusion

NOD1 (Glu266Lys) and NOD2 (Arg702Trp and Gly908Arg) polymorphisms were associated with an increased susceptibility to GBS. These polymorphisms could be genetic marker to GBS susceptibility."xsd:string
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http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/author"Prasad K.N."xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/author"Modi D.R."xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/author"Paliwal V.K."xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/author"Kharwar N.K."xsd:string
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http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/name"J Neurol Sci"xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/pages"57-62"xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/title"Association of NOD1 and NOD2 polymorphisms with Guillain-Barre syndrome in Northern Indian population."xsd:string
http://purl.uniprot.org/citations/27000222http://purl.uniprot.org/core/volume"363"xsd:string
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