| http://purl.uniprot.org/citations/27000970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27000970 | http://www.w3.org/2000/01/rdf-schema#comment | "As part of a search for selective, mechanism-based covalent inhibitors of human pancreatic α-amylase we describe the chemoenzymatic synthesis of the disaccharide analog α-glucosyl epi-cyclophellitol, demonstrate its stoichiometric reaction with human pancreatic α-amylase and evaluate the time dependence of its inhibition. X-ray crystallographic analysis of the covalent derivative so formed confirms its reaction at the active site with formation of a covalent bond to the catalytic nucleophile D197. The structure illuminates the interactions with the active site and confirms OH4' on the nonreducing end sugar as a good site for attachment of fluorescent tags in generating probes for localization and quantitation of amylase in vivo."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12143"xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Withers S.G."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Nguyen N.T."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Chen H.M."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Brayer G.D."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Caner S."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/author | "Overkleeft H."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/pages | "1143-1151"xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/title | "Glucosyl epi-cyclophellitol allows mechanism-based inactivation and structural analysis of human pancreatic alpha-amylase."xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://purl.uniprot.org/core/volume | "590"xsd:string |
| http://purl.uniprot.org/citations/27000970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27000970 |
| http://purl.uniprot.org/citations/27000970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27000970 |
| http://purl.uniprot.org/uniprot/#_P04746-mappedCitation-27000970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27000970 |
| http://purl.uniprot.org/uniprot/P04746 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27000970 |