| http://purl.uniprot.org/citations/27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27001958 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously we have shown that transcription factor Foxp1 plays an essential role in maintaining naive T cell quiescence; in the absence of Foxp1, mature naive CD8(+) T cells proliferate in direct response to homeostatic cytokine IL-7. In this study, we report that the deletion of Foxp1 in naive CD8(+) T cells leads to enhanced activation of the PI3K/Akt/mammalian target of rapamycin signaling pathway and its downstream cell growth and metabolism targets in response to IL-7. We found that Foxp1 directly regulates PI3K interacting protein 1, a negative regulator of PI3K. Additionally, we found that deletion of Foxp1 in naive CD8(+) T cells results in increased expression levels of E2fs, the critical components for cell cycle progression and proliferation, in a manner that is not associated with increased phosphorylation of retinoblastoma protein. Taken together, our studies suggest that Foxp1 enforces naive CD8(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1501896"xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Geng J."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Yao M."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Wang Y.H."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Shi B."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Sprout S.L."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/author | "Stevens A.C."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/pages | "3537-3541"xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/title | "Cutting Edge: Foxp1 Controls Naive CD8+ T Cell Quiescence by Simultaneously Repressing Key Pathways in Cellular Metabolism and Cell Cycle Progression."xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/27001958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27001958 |
| http://purl.uniprot.org/citations/27001958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27001958 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J282-mappedCitation-27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27001958 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1H9-mappedCitation-27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27001958 |
| http://purl.uniprot.org/uniprot/#_D3Z6Q3-mappedCitation-27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27001958 |
| http://purl.uniprot.org/uniprot/#_H3BJ24-mappedCitation-27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27001958 |
| http://purl.uniprot.org/uniprot/#_P58462-mappedCitation-27001958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27001958 |