| http://purl.uniprot.org/citations/27005833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27005833 | http://www.w3.org/2000/01/rdf-schema#comment | "CCAAT/enhancer-binding protein alpha (C/EBPα) is an essential transcription factor for myeloid lineage commitment. Here we demonstrate that acetylation of C/EBPα at lysine residues K298 and K302, mediated at least in part by general control non-derepressible 5 (GCN5), impairs C/EBPα DNA-binding ability and modulates C/EBPα transcriptional activity. Acetylated C/EBPα is enriched in human myeloid leukaemia cell lines and acute myeloid leukaemia (AML) samples, and downregulated upon granulocyte-colony stimulating factor (G-CSF)-mediated granulocytic differentiation of 32Dcl3 cells. C/EBPα mutants that mimic acetylation failed to induce granulocytic differentiation in C/EBPα-dependent assays, in both cell lines and in primary hematopoietic cells. Our data uncover GCN5 as a negative regulator of C/EBPα and demonstrate the importance of C/EBPα acetylation in myeloid differentiation."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms10968"xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Wee S."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Ray D."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Levantini E."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Weigert O."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Bararia D."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Kwok H.S."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Numata A."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Welner R.S."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Ebralidze A.K."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Gunaratne J."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Sarosi M.B."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/author | "Tschuri S."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/pages | "10968"xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/title | "Acetylation of C/EBPalpha inhibits its granulopoietic function."xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27005833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27005833 |
| http://purl.uniprot.org/citations/27005833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27005833 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPE0-mappedCitation-27005833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27005833 |