| http://purl.uniprot.org/citations/27007846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27007846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27007846 | http://www.w3.org/2000/01/rdf-schema#comment | "The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. Here we present the structure of human TFIID in complex with TFIIA and core promoter DNA, determined by single-particle cryo-electron microscopy at sub-nanometre resolution. All core promoter elements are contacted by subunits of TFIID, with TAF1 and TAF2 mediating major interactions with the downstream promoter. TFIIA bridges the TBP-TATA complex with lobe B of TFIID. We also present the cryo-electron microscopy reconstruction of a fully assembled human TAF-less PIC. Superposition of common elements between the two structures provides novel insights into the general role of TFIID in promoter recognition, PIC assembly, and transcription initiation."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17394"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17394"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Fang J."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Fang J."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Nogales E."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Chacon P."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Chacon P."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Lopez-Blanco J.R."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Lopez-Blanco J.R."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Louder R.K."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/author | "Louder R.K."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/pages | "604-609"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/pages | "604-609"xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/title | "Structure of promoter-bound TFIID and model of human pre-initiation complex assembly."xsd:string |
| http://purl.uniprot.org/citations/27007846 | http://purl.uniprot.org/core/title | "Structure of promoter-bound TFIID and model of human pre-initiation complex assembly."xsd:string |