| http://purl.uniprot.org/citations/27008177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27008177 | http://www.w3.org/2000/01/rdf-schema#comment | "Cullin-3 (CUL3)-based ubiquitin ligases regulate endosome maturation and trafficking of endocytic cargo to lysosomes in mammalian cells. Here, we report that these functions depend on SPOPL, a substrate-specific CUL3 adaptor. We find that SPOPL associates with endosomes and is required for both the formation of multivesicular bodies (MVBs) and the endocytic host cell entry of influenza A virus. In SPOPL-depleted cells, endosomes are enlarged and fail to acquire intraluminal vesicles (ILVs). We identify a critical substrate ubiquitinated by CUL3-SPOPL as EPS15, an endocytic adaptor that also associates with the ESCRT-0 complex members HRS and STAM on endosomes. Indeed, EPS15 is ubiquitinated in a SPOPL-dependent manner, and accumulates with HRS in cells lacking SPOPL. Together, our data indicates that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking and MVB formation by ubiquitinating and degrading EPS15 at endosomes, thereby influencing influenza A virus infection as well as degradation of EGFR and other EPS15 targets."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.13841"xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Helenius A."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Greber U.F."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Peter M."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Barnes C.A."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Enchev R.I."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Stoffel-Studer I."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Ulbricht A."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Meyer-Schaller N."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Huotari J."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/author | "Gschweitl M."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/pages | "e13841"xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/title | "A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes."xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27008177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27008177 |
| http://purl.uniprot.org/citations/27008177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27008177 |
| http://purl.uniprot.org/uniprot/#_B7Z240-mappedCitation-27008177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27008177 |
| http://purl.uniprot.org/uniprot/#_B3KR37-mappedCitation-27008177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27008177 |
| http://purl.uniprot.org/uniprot/#_B4DEY7-mappedCitation-27008177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27008177 |
| http://purl.uniprot.org/uniprot/#_B7Z600-mappedCitation-27008177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27008177 |