| http://purl.uniprot.org/citations/27009467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27009467 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoid-related orphan receptor gamma t (RORγt) is a master transcription factor central to type 17 immunity involving cells such as T helper 17, group 3 innate lymphoid cells or IL-17-producing γδ T cells. Here we show that the intracellular ion channel TMEM176B and its homologue TMEM176A are strongly expressed in these RORγt(+) cells. We demonstrate that TMEM176A and B exhibit a similar cation channel activity and mainly colocalise in close proximity to the trans-Golgi network. Strikingly, in the mouse, the loss of Tmem176b is systematically associated with a strong upregulation of Tmem176a. While Tmem176b single-deficiency has no effect on the course of experimental autoimmune encephalomyelitis, T cell or DSS-induced colitis, it significantly reduces imiquimod-induced psoriasis-like skin inflammation. These findings shed light on a potentially novel specific process linked to post-Golgi trafficking for modulating the function of RORγt(+) cells and indicate that both homologues should be simultaneously targeted to clearly elucidate the role of this intracellular ion flow."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep23682"xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Moreau A."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Charnet P."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Martin J.C."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Lancien M."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Lemoine A."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Fehling H.J."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Bouchet-Delbos L."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Josien R."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Beriou G."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Chiffoleau E."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Louvet C."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Cens T."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Cuturi M.C."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Bienvenu G."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Guillot F."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Nicot A.B."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/author | "Drujont L."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/pages | "23682"xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/title | "RORgammat+ cells selectively express redundant cation channels linked to the Golgi apparatus."xsd:string |
| http://purl.uniprot.org/citations/27009467 | http://purl.uniprot.org/core/volume | "6"xsd:string |