http://purl.uniprot.org/citations/27011106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27011106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27011106 | http://www.w3.org/2000/01/rdf-schema#comment | "During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining intermediates as non-crossovers (NCOs). We show that the Caenorhabditis elegans RMI1 homolog-1 (RMH-1) functions during meiosis to promote both CO and NCO HR at appropriate chromosomal sites. RMH-1 accumulates at CO sites, dependent on known pro-CO factors, and acts to promote CO designation and enforce the CO outcome of HR-intermediate resolution. RMH-1 also localizes at NCO sites and functions in parallel with SMC-5 to antagonize excess HR-based connections between chromosomes. Moreover, RMH-1 also has a major role in channeling DSBs into an NCO HR outcome near the centers of chromosomes, thereby ensuring that COs form predominantly at off-center positions."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1002412"xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1002412"xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Paulin L."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Paulin L."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Tang L."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Tang L."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Tam A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Tam A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "von Haeseler A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "von Haeseler A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Jagut M."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Jagut M."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Jantsch V."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Jantsch V."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Woglar A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Woglar A."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Dello Stritto M.R."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Dello Stritto M.R."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Gallach M."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Gallach M."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Habacher C."xsd:string |
http://purl.uniprot.org/citations/27011106 | http://purl.uniprot.org/core/author | "Habacher C."xsd:string |