http://purl.uniprot.org/citations/27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27012032 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAbnormal expression of NRF2 levels in some tumor tissues may enhance drug resistance through various mechanisms. Recent studies have demonstrated a link between dysregulated expression of miRNAs and breast carcinogenesis.MethodsQuantitative RT-PCR analysis was used to examine the expression levels of miR-153 in breast cancer cell lines. The biological effects of miR-153 were assessed in CRC cell lines using clonogenic cell survival assay, mammosphere formation assay, cell migration assay, 8-OHdG estimation assay, and flow cytometry analysis. Quantitative RT-PCR and western blot analyses were employed to evaluate the expression of miR-153 targets. In this study, we investigated the role of vitamin C in the regulation of miR-153 (miR-153) and its target gene(s) in cell models of mammary carcinogenesis.ResultsIn human breast cell lines treated with E2, the level of miR-153 was found to be increased. In contrast, vitamin C treatment was able to decrease the expression of miR-153. Bioinformatic prediction indicates nuclear factor erythroid 2-related factor 2 (NRF2) may be a target for miR-153. In E2-treated breast cancer cell lines, NRF2 protein level was found to be decreased. Overexpression of miR-153 significantly reduced NRF2 and the downstream genes. Furthermore, miR-153 was found to decrease apoptosis and increase colony formation in breast epithelial cells.ConclusionsThese data indicate that miR-153 acts as an oncogene in breast carcinogenesis by targeting NRF2."xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.org/dc/terms/identifier | "doi:10.7754/clin.lab.2015.150518"xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/author | "Teng Y."xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/name | "Clin Lab"xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/pages | "39-47"xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/title | "MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis."xsd:string |
http://purl.uniprot.org/citations/27012032 | http://purl.uniprot.org/core/volume | "62"xsd:string |
http://purl.uniprot.org/citations/27012032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27012032 |
http://purl.uniprot.org/citations/27012032 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27012032 |
http://purl.uniprot.org/uniprot/#_E2I973-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_B7ZA33-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A0A8V8TN14-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A0A8V8TPA8-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A0A8I6A7Z8-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A6HMF7-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A6HMF8-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A6HMF9-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_A6HMG0-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_B4DNB0-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_Q16236-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |
http://purl.uniprot.org/uniprot/#_O54968-mappedCitation-27012032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012032 |