| http://purl.uniprot.org/citations/27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27012192 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostate cancer is the most diagnosed cancer in men and multiple risk factors and genetic alterations have been described. The TMPRSS2-ERG fusion event and the overexpression of the transcription factor ERG are present in approximately 50% of all prostate cancer patients, however, the clinical outcome is still controversial. Prostate tumors produce various soluble factors, including the pleiotropic cytokine IL-6, regulating cellular processes such as proliferation and metastatic segregation. Here, we used prostatectomy samples in a tissue microarray format and analyzed the co-expression and the clinicopathologic data of ERG and IL-6 using immunohistochemical double staining and correlated the read-out with clinicopathologic data. Expression of ERG and IL-6 correlated strongly in prostate tissue samples. Forced expression of ERG in prostate tumor cell lines resulted in significantly increased secretion of IL-6, whereas the down-regulation of ERG decreased IL-6 secretion. By dissecting the underlying mechanism in prostate tumor cell lines we show the ERG-mediated up-regulation of the prostanoid receptors EP2 and EP3. The prostanoid receptor EP2 was overexpressed in human prostate cancer tissue. Furthermore, the proliferation rate and IL-6 secretion in DU145 cells was reduced after treatment with EP2-receptor antagonist. Collectively, our study shows that the expression of ERG in prostate cancer is linked to the expression of IL-6 mediated by the prostanoid receptor EP2."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2015.12.009"xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Nowak M."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Vogel W."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Duensing S."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Merz C."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Kirfel J."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Perner S."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Andren O."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "Queisser A."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/author | "von Massenhausen A."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/pages | "974-984"xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/title | "IL-6 Overexpression in ERG-Positive Prostate Cancer Is Mediated by Prostaglandin Receptor EP2."xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/27012192 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27012192 |
| http://purl.uniprot.org/citations/27012192 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27012192 |
| http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |
| http://purl.uniprot.org/uniprot/#_B4DVM1-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |
| http://purl.uniprot.org/uniprot/#_B4DNV3-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |
| http://purl.uniprot.org/uniprot/#_B4DNQ5-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |
| http://purl.uniprot.org/uniprot/#_B5MC21-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |
| http://purl.uniprot.org/uniprot/#_H9C875-mappedCitation-27012192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27012192 |