| http://purl.uniprot.org/citations/27013173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27013173 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein arginine methyltransferase 1 (PRMT1), a major PRMT in mammalian cells, has been shown to play a crucial role in multiple biological functions in vitro. To explore the role of PRMT1 in B cells in vivo, we generated B cell-specific PRMT1-deficient (Prmt1(-/-) ) mice using a Cre-loxP system. Prmt1(-/-) mice showed a defect in B-cell development with diminished levels of serum antibodies. Antibody responses in Prmt1(-/-) mice were absent after stimulation with the type 2 T cell-independent antigen NP-Ficoll but intact after stimulation with the T cell-dependent antigen NP-OVA. Our findings comprise the first evidence showing that PRMT1 is necessary for lymphocyte functions in vivo."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12161"xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Mizuguchi J."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Kiyonari H."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Hata K."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Yokosuka T."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Mukumoto Y."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/author | "Yanase N."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/pages | "1200-1210"xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/title | "Differential regulation of T-cell dependent and T-cell independent antibody responses through arginine methyltransferase PRMT1 in vivo."xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://purl.uniprot.org/core/volume | "590"xsd:string |
| http://purl.uniprot.org/citations/27013173 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27013173 |
| http://purl.uniprot.org/citations/27013173 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27013173 |
| http://purl.uniprot.org/uniprot/#_A0A140LHF7-mappedCitation-27013173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27013173 |
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| http://purl.uniprot.org/uniprot/#_A0A140LJF4-mappedCitation-27013173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27013173 |