| http://purl.uniprot.org/citations/27022143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27022143 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the role of NFκB1 in the homeostasis and function of peripheral follicular (Fo) B cells. Aging mice lacking NFκB1 (Nfκb1(-/-)) develop lymphoproliferative and multiorgan autoimmune disease attributed in large part to the deregulated activity of Nfκb1(-/-)Fo B cells that produce excessive levels of the proinflammatory cytokine interleukin 6 (IL-6). Despite enhanced germinal center (GC) B cell differentiation, the formation of GC structures was severely disrupted in the Nfκb1(-/-)mice. Bone marrow chimeric mice revealed that the Fo B cell-intrinsic loss of NFκB1 led to the spontaneous generation of GC B cells. This was primarily the result of an increase in IL-6 levels, which promotes the differentiation of Fo helper CD4(+)T cells and acts in an autocrine manner to reduce antigen receptor and toll-like receptor activation thresholds in a population of proliferating IgM(+)Nfκb1(-/-)Fo B cells. We demonstrate that p50-NFκB1 represses Il-6 transcription in Fo B cells, with the loss of NFκB1 also resulting in the uncontrolled RELA-driven transcription of Il-6.Collectively, our findings identify a previously unrecognized role for NFκB1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20151182"xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Corcoran L.M."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Banerjee A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Vasanthakumar A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Willis S.N."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Mackay F."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "O'Reilly L.A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Kallies A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Gerondakis S."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Hibbs M.L."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Maxwell M.J."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Hodgkin P.D."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Grigoriadis G."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Gugasyan R."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Febbraio M.A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Fairfax K.A."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Tsantikos E."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "de Valle E."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/author | "Cornish J.K."xsd:string |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27022143 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |