| http://purl.uniprot.org/citations/27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27026582 | http://www.w3.org/2000/01/rdf-schema#comment | "The β-like globin genes are developmental stage specifically transcribed in erythroid cells. The transcription of the β-like globin genes requires erythroid specific activators such as GATA-1, NF-E2, TAL1 and KLF1. However, the roles of these activators have not fully elucidated in transcription of the human adult β-globin gene. Here we employed hybrid MEL cells (MEL/ch11) where a human chromosome containing the β-globin locus is present and the adult β-globin gene is highly transcribed by induction. The roles of erythroid specific activators were analyzed by inhibiting the expression of NF-E2, TAL1 or KLF1 in MEL/ch11 cells. The loss of each activator decreased the transcription of human β-globin gene, locus wide histone hyperacetylation and the binding of other erythroid specific activators including GATA-1, even though not affecting the expression of other activators. Notably, sensitivity to DNase I was reduced in the locus control region (LCR) hypersensitive sites (HSs) with the depletion of activators. These results indicate that NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR. It might contribute to the transcription of human adult β-globin gene by allowing the access of activators and cofactors. The roles of activators in the adult β-globin locus appear to be different from the roles in the early fetal locus."xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2016.03.013"xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/author | "Kim Y.W."xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/author | "Kim A."xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/author | "Yun W.J."xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/pages | "45-52"xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/title | "Erythroid activator NF-E2, TAL1 and KLF1 play roles in forming the LCR HSs in the human adult beta-globin locus."xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/27026582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27026582 |
| http://purl.uniprot.org/citations/27026582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A140KFU0-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_Q0Z944-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A1U9WYY8-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A2R3Z0D6-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A3G9CLN8-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A1YZ08-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A650F0N3-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A385KNS9-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A172M5U0-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A0U4CJG7-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A0U4D3U3-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |
| http://purl.uniprot.org/uniprot/#_A0A0U4DAW6-mappedCitation-27026582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27026582 |