| http://purl.uniprot.org/citations/27027282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27027282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27027282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/27027282 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N(6)-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N(6)-methyladenine. An increase of N(6)-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N(6)-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched at young (<1.5 million years old) but not old (>6 million years old) L1 elements. The deposition of N(6)-methyladenine correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell differentiation. As young full-length LINE-1 transposons are strongly enriched on the X chromosome, genes located on the X chromosome are also silenced. Thus, N(6)-methyladenine developed a new role in epigenetic silencing in mammalian evolution distinct from its role in gene activation in other organisms. Our results demonstrate that N(6)-methyladenine constitutes a crucial component of the epigenetic regulation repertoire in mammalian genomes."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17640"xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature17640"xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Fang G."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Fang G."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Lai Y."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Lai Y."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Zhong M."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Zhong M."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Lin K."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Lin K."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Byrum S.D."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Byrum S.D."xsd:string |
| http://purl.uniprot.org/citations/27027282 | http://purl.uniprot.org/core/author | "Hon L.S."xsd:string |