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http://purl.uniprot.org/citations/27033174 | http://www.w3.org/2000/01/rdf-schema#comment | "The interleukin (IL)-17A/IL-17 receptor A (IL-17RA) axis is emerging as a key player in host defence. Several studies have demonstrated that IL-17A-mediated responses play a critical role in both acute and chronic inflammation induced by infectious agents, environmental stimuli and genetic diseases in the airways. In this regard, it is becoming evident that IL-17A/IL-17RA signalling may have a protective and beneficial impact on health, but that it can also result in detrimental outcomes. On one hand, the IL-17A/IL-17RA axis can contribute to the elimination of noxious stimuli and to the resolution of acute inflammatory processes; on the other hand, it can exacerbate immunopathological responses, contributing to the development and progression of chronic respiratory illnesses. In addition, cellular and molecular signatures underlying IL-17A/IL-17RA signalling have been increasingly identified, although further studies are needed to clarify such complex responses. Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology."xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cytogfr.2016.03.009"xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/author | "Bragonzi A."xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/author | "Cigana C."xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/author | "Lore N.I."xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/name | "Cytokine Growth Factor Rev"xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/pages | "19-27"xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/title | "The IL-17A/IL-17RA axis in pulmonary defence and immunopathology."xsd:string |
http://purl.uniprot.org/citations/27033174 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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