| http://purl.uniprot.org/citations/27034374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27034374 | http://www.w3.org/2000/01/rdf-schema#comment | "Host responses against metazoan parasites or an array of environmental substances elicit type 2 immunity. Despite its protective function, type 2 immunity also drives allergic diseases. The mechanisms that regulate the magnitude of the type 2 response remain largely unknown. Here, we show that genetic ablation of a receptor tyrosine kinase encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity. Furthermore, the TYRO3 agonist PROS1 was induced in T cells by the quintessential type 2 cytokine, interleukin-4. T cell-specificPros1knockouts phenocopied the loss ofTyro3 Thus, a PROS1-mediated feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the intensity of type 2 responses."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaf1358"xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Hao L."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Hu D."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Rothlin C.V."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Eng C."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Huntsman S."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Herbert D.R."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Burchard E.G."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Chan P.Y."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Craft J.E."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Torgerson D.G."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Correale J."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Carrera Silva E.A."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Repetto S."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Weinstein J.S."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Licona-Limon P."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "De Kouchkovsky D."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/author | "Joannas L.D."xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/27034374 | http://purl.uniprot.org/core/pages | "99-103"xsd:string |