| http://purl.uniprot.org/citations/27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27035432 | http://www.w3.org/2000/01/rdf-schema#comment | "β-adrenergic receptors (β-ARs) play an important role in cardiac remodeling, which is the key pathological process in various heart diseases and leads to heart failure. However, the regulation of β-AR expression in remodeling hearts is still unclear. This study aims to clarify the possible mechanisms underlying the regulation of β1- and β2-AR expression in cardiac remodeling. The rat model of cardiac remodeling was established by subcutaneous injection of isoproterenol(ISO) at the dose of 0.25 mg·kg(-1)·d(-1) for 7 days. We found that the expression of β1- and β2-ARs decreased in the remodeling heart. The mechanisms may include the inhibition of DNA transcription and the increase of mRNA degradation. cAMP-response element binding protein(CREB) is a well-known transcription factor of β-AR. However, the expression and activation of CREB was not changed in the remodeling heart. Further, human Antigen-R (HuR), a RNA binding protein, which binds to the 3'-untranslated region of the β-AR mRNA and promotes RNA degradation, was increased in the remodeling model. And in vitro, HuR deficiency reversed the reduction of β-AR mRNA induced by ISO. Therefore, the present findings indicate that HuR, but not CREB, is responsible for the reduction of β-AR expression in ISO induced cardiac remodeling."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0152005"xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Yin Q."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Zheng X."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Lv Z."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/author | "Zheng X.'"xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/pages | "e0152005"xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/title | "Downregulation of beta-Adrenoceptors in Isoproterenol-Induced Cardiac Remodeling through HuR."xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/27035432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27035432 |
| http://purl.uniprot.org/citations/27035432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27035432 |
| http://purl.uniprot.org/uniprot/#_A0A0M4LAM5-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSP7-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |
| http://purl.uniprot.org/uniprot/#_A6JI28-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |
| http://purl.uniprot.org/uniprot/#_D7NIV9-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |
| http://purl.uniprot.org/uniprot/#_P18090-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |
| http://purl.uniprot.org/uniprot/#_P10608-mappedCitation-27035432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035432 |