| http://purl.uniprot.org/citations/27035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27035620 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of cellular adhesion leads to the progression of breast cancer through acquisition of anchorage independence, also known as resistance to anoikis. Although inactivation of E-cadherin is essential for acquisition of anoikis resistance, it has remained unclear how metastatic breast cancer cells counterbalance the induction of apoptosis without E-cadherin-dependent cellular adhesion. We report here that E-cadherin inactivation in breast cancer cells induces PI3K/AKT-dependent FOXO3 inhibition and identify FOXO3 as a novel and direct transcriptional activator of the pro-apoptotic protein BMF. As a result, E-cadherin-negative breast fail to upregulate BMF upon transfer to anchorage independence, leading to anoikis resistance. Conversely, expression of BMF in E-cadherin-negative metastatic breast cancer cells is sufficient to inhibit tumour growth and dissemination in mice. In conclusion, we have identified repression of BMF as a major cue that underpins anoikis resistance and tumour dissemination in E-cadherin-deficient metastatic breast cancer."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2016.33"xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Dansen T.B."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Burgering B.M."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "van Triest M.H."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Hornsveld M."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Derksen P.W."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Smits A.M."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Kloet D.E."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "van Amersfoort M."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "van de Ven R.A."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/author | "Tenhagen M."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/pages | "1483-1492"xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/title | "Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancer."xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/27035620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27035620 |
| http://purl.uniprot.org/citations/27035620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27035620 |
| http://purl.uniprot.org/uniprot/#_A2AV74-mappedCitation-27035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035620 |
| http://purl.uniprot.org/uniprot/#_A2AV75-mappedCitation-27035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035620 |
| http://purl.uniprot.org/uniprot/#_Q3TAQ6-mappedCitation-27035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035620 |
| http://purl.uniprot.org/uniprot/#_Q91ZE9-mappedCitation-27035620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27035620 |
| http://purl.uniprot.org/uniprot/Q91ZE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27035620 |