| http://purl.uniprot.org/citations/27040500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27040500 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this duplication event--UPF3B--is critical for the nonsense-mediated RNA decay (NMD) pathway, while its autosomal counterpart--UPF3A--encodes an enigmatic protein previously shown to have trace NMD activity. Using loss-of-function approaches in vitro and in vivo, we discovered that UPF3A acts primarily as a potent NMD inhibitor that stabilizes hundreds of transcripts. Evidence suggests that UPF3A acquired repressor activity through simple impairment of a critical domain, a rapid mechanism that may have been widely used in evolution. Mice conditionally lacking UPF3A exhibit "hyper" NMD and display defects in embryogenesis and gametogenesis. Our results support a model in which UPF3A serves as a molecular rheostat that directs developmental events."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2016.02.046"xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "McCarrey J.R."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Wilkinson M.F."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Shum E.Y."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Ramaiah M."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Chan W.K."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Espinoza J.L."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Peterson K.J."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Jones S.H."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "De Rooij D.G."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Shao A."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Song H.W."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Lou C.H."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Cook-Andersen H."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Phan M.H."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Chousal J.N."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/author | "Krause M.D."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/pages | "382-395"xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/title | "The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay."xsd:string |
| http://purl.uniprot.org/citations/27040500 | http://purl.uniprot.org/core/volume | "165"xsd:string |