| http://purl.uniprot.org/citations/27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27045525 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11158"xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Hattori K."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Okabe K."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Naguro I."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Furutani S."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/author | "Funatsu T."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/pages | "11158"xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/title | "ASK1 signalling regulates brown and beige adipocyte function."xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27045525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27045525 |
| http://purl.uniprot.org/citations/27045525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27045525 |
| http://purl.uniprot.org/uniprot/#_A0A1L1ST18-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_D3YVC4-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_D3Z5H1-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TMH5-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_B4DF67-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_E9PWG9-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_Q14AY4-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |
| http://purl.uniprot.org/uniprot/#_O35099-mappedCitation-27045525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27045525 |