| http://purl.uniprot.org/citations/27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27046536 | http://www.w3.org/2000/01/rdf-schema#comment | "Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood. We discovered requirements for T-box at multiple stages of mouse limb development and distinct molecular functions in different tissue compartments. Early loss of T-box3 disrupts limb initiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants. Later ablation of T-box3 in posterior limb mesenchyme causes digit loss. In contrast, loss of anterior T-box3 results in preaxial polydactyly, as seen with dysfunction of primary cilia or Gli3-repressor. Remarkably, T-box3 is present in primary cilia where it colocalizes with Gli3. T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu complex that regulates Gli3 stability and processing. Thus, T-box3 controls digit number upstream of Shh-dependent (posterior mesenchyme) and Shh-independent, cilium-based (anterior mesenchyme) Hedgehog pathway function."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07897"xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Moon A.M."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Moore B."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Mirshahi T."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Rozenberg J.M."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Emechebe U."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Firment A."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/author | "Kumar P P."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/pages | "e07897"xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/title | "T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number."xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27046536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27046536 |
| http://purl.uniprot.org/citations/27046536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27046536 |
| http://purl.uniprot.org/uniprot/P70324#attribution-402E4A507D73E21548A60CAF39ABD2B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/P70324#attribution-C7ED40B791AB351DEE399D040E05AA6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_D3Z7B6-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTS5-mappedCitation-27046536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27046536 |