| http://purl.uniprot.org/citations/27050074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27050074 | http://www.w3.org/2000/01/rdf-schema#comment | "New reliable biomarkers are needed to predict the response to immune checkpoint inhibitors against programmed death-1 (PD-1) and its ligand (PD-L1), because PD-L1 expression on tumor cells has limited power for selecting patients who may benefit from such therapy. Here we investigated the significance of PD-L1 and PD-L2 gene copy number gains using fluorescence in situ hybridization as well as PD-L1 and PD-L2 expression in 654 patients with resected non-small-cell lung cancer. The prevalence of PD-L1 amplification and polysomy was 3.1% and 13.2%, respectively. The PD-L1 gene copy number status was in agreement with both the PD-L2 and Janus kinase 2 gene copy number statuses. PD-L1 and PD-L2 expression was observed in 30.7% and 13.1%, respectively. Both PD-L1 copy number gains and expression were associated with smoking-related tumors. Tumor cells with PD-L1 genomic gains exhibited significantly higher levels of PD-L1 expression than those without, but PD-L2 copy number gains were not related to PD-L2 augmentation. PD-L1 gene amplification and polysomy were independently associated with PD-L1 expression, with high immune infiltrates and EGFR expression in a multivariate logistic regression model. Comparative analysis between primary tumors and synchronous regional lymph node metastases revealed that the PD-L1 gene copy number alterations were highly consistent and reproducible compared with the PD-L1 expression. Both PD-L1 amplification and level of protein expression were predictors of poor survival using Cox univariate analyses. Therefore, we conclude that an increase in PD-L1 gene copy number can be a feasible alternative biomarker for predicting response to anti-PD-1/PD-L1 therapy."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.8528"xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Ogawa H."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Niwa H."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Yoshimura K."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Suda T."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Kurabe N."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Shinmura K."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Sugimura H."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Tanahashi M."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Kahyo T."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Inui N."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Funai K."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/author | "Kawase A."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/pages | "32113-32128"xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/title | "Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27050074 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27050074 |
| http://purl.uniprot.org/citations/27050074 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27050074 |