| http://purl.uniprot.org/citations/27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27052181 | http://www.w3.org/2000/01/rdf-schema#comment | "The cJun NH2-terminal kinase (JNK) signaling pathway is required for the development of hepatitis and hepatocellular carcinoma. A role for JNK in liver parenchymal cells has been proposed, but more recent studies have implicated non-parenchymal liver cells as the relevant site of JNK signaling. Here, we tested the hypothesis that myeloid cells mediate this function of JNK. We show that mice with myeloid cell-specific JNK deficiency exhibit reduced hepatic inflammation and suppression of both hepatitis and hepatocellular carcinoma. These data identify myeloid cells as a site of pro-inflammatory signaling by JNK that can promote liver pathology. Targeting myeloid cells with a drug that inhibits JNK may therefore provide therapeutic benefit for the treatment of inflammation-related liver disease."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.03.008"xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/author | "Barrett T."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/author | "Han M.S."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/author | "Brehm M.A."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/pages | "19-26"xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/title | "Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27052181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27052181 |
| http://purl.uniprot.org/citations/27052181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27052181 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_D3Z1Z4-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPL3-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_A3KBF5-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_A6P3E4-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_G3X8U9-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_P08905-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_Q544A0-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_Q5NCK8-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_Q7TSJ7-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |
| http://purl.uniprot.org/uniprot/#_Q8C094-mappedCitation-27052181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27052181 |