| http://purl.uniprot.org/citations/27060486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27060486 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased glutamatergic neurotransmission appears to mediate the reinforcing properties of drugs of abuse, including ethanol (EtOH). We have shown that administration of ceftriaxone (CEF), a β-lactam antibiotic, reduced EtOH intake and increased glutamate transporter 1 (GLT-1) expression in mesocorticolimbic regions of male and female alcohol-preferring (P) rats. In the present study, we tested whether CEF administration would reduce nicotine (NIC) and/or EtOH intake by adult female P rats. P rats were randomly assigned to 4 groups: (a) 5% sucrose (SUC) or 10% SUC [SUC], (b) 5% SUC+0.07mg/ml NIC and 10% SUC+0.14mg/ml NIC [NIC-SUC], 15% EtOH and 30% EtOH [EtOH] and (d) 15% EtOH+0.07mg/ml NIC and 30% EtOH+0.14mg/ml NIC [NIC-EtOH]. After achieving stable intakes (4weeks), the rats were administered 7 consecutive, daily i.p. injections of either saline or 200mg/kg CEF. The effects of CEF on intake were significant but differed across the reinforcers; such that ml/kg/day SUC was reduced by ∼30%, mg/kg/day NIC was reduced by ∼70% in the NIC-SUC group and ∼40% in the EtOH-NIC group, whereas g/kg/day EtOH was reduced by ∼40% in both the EtOH and EtOH-NIC group. The effects of CEF on GLT-1 expression were also studied. We found that CEF significantly increased GLT-1 expression in the prefrontal cortex and the nucleus accumbens of the NIC and NIC-EtOH rats as compared to NIC and NIC-EtOH saline-treated rats. These findings provide further support for GLT-1-associated mechanisms in EtOH and/or NIC abuse. The present results along with previous reports of CEF's efficacy in reducing cocaine self-administration in rats suggest that modulation of GLT-1 expression and/or activity is an important pharmacological target for treating polysubstance abuse and dependence."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2016.04.004"xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/author | "Bell R.L."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/author | "Sari Y."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/author | "Rao P.S.S."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/author | "Toalston J.E."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/pages | "117-125"xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/title | "Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression."xsd:string |
| http://purl.uniprot.org/citations/27060486 | http://purl.uniprot.org/core/volume | "326"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q6DUJ5-mappedCitation-27060486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27060486 |