| http://purl.uniprot.org/citations/27060915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27060915 | http://www.w3.org/2000/01/rdf-schema#comment | "The treatment of critical size bone defects represents a challenge. The growth factor bone morphogenetic protein 2 (BMP-2) is clinically established but has potentially adverse effects when used at high doses. The aim of this study was to evaluate if stromal derived factor-1 alpha (SDF-1α) and BMP-2 released from heparinized mineralized collagen type I matrix (MCM) scaffolds have a cumulative effect on bone regeneration. MCM scaffolds were functionalized with heparin, loaded with BMP-2 and/or SDF-1α and implanted into a murine critical size femoral bone defect (control group, low dose BMP-2 group, low dose BMP-2 + SDF-1α group, and high dose BMP-2 group). After 6 weeks, both the low dose BMP-2 + SDF-1α group (5.8 ± 0.6 mm³, p = 0.0479) and the high dose BMP-2 group (6.5 ± 0.7 mm³, p = 0.008) had a significantly increased regenerated bone volume compared to the control group (4.2 ± 0.5 mm³). There was a higher healing score in the low dose BMP-2 + SDF-1α group (median grade 8; Q1-Q3 7-9; p = 0.0357) than in the low dose BMP-2 group (7; Q1-Q3 5-9) histologically. This study showed that release of BMP-2 and SDF-1α from heparinized MCM scaffolds allows for the reduction of the applied BMP-2 concentration since SDF-1α seems to enhance the osteoinductive potential of BMP-2. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2126-2134, 2016."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbm.a.35744"xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Lee G."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Bernhardt R."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Jacobi A."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Gunther K.P."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Goodman S.B."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Muders M."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Gelinsky M."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Stiehler M."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Rammelt S."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Vater C."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Knaack S."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Langanke R."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Niederlohmann E."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Sensenschmidt M."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/author | "Zwingenberger S."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/name | "J Biomed Mater Res A"xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/pages | "2126-2134"xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/title | "The effect of SDF-1alpha on low dose BMP-2 mediated bone regeneration by release from heparinized mineralized collagen type I matrix scaffolds in a murine critical size bone defect model."xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/27060915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27060915 |
| http://purl.uniprot.org/citations/27060915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27060915 |