| http://purl.uniprot.org/citations/27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27061092 | http://www.w3.org/2000/01/rdf-schema#comment | "Adrenocorticotropic hormone (ACTH) treatment has been proven to promote paxillin dephosphorylation and increase soluble protein tyrosine phosphatase (PTP) activity in rat adrenal zona fasciculata (ZF). Also, in-gel PTP assays have shown the activation of a 115-kDa PTP (PTP115) by ACTH. In this context, the current work presents evidence that PTP115 is PTP-PEST, a PTP that recognizes paxillin as substrate. PTP115 was partially purified from rat adrenal ZF and PTP-PEST was detected through Western blot in bioactive samples taken in each purification step. Immunohistochemical and RT-PCR studies revealed PTP-PEST expression in rat ZF and Y1 adrenocortical cells. Moreover, a PTP-PEST siRNA decreased the expression of this phosphatase. PKA phosphorylation of purified PTP115 isolated from non-ACTH-treated rats increased KM and VM . Finally, in-gel PTP assays of immunoprecipitated paxillin from control and ACTH-treated rats suggested a hormone-mediated increase in paxillin-PTP115 interaction, while PTP-PEST and paxillin co-localize in Y1 cells. Taken together, these data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction. J. Cell. Biochem. 117: 2170-2181, 2016. © 2016 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals, Inc."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.25566"xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Gorostizaga A.B."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Maloberti P.M."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Mendez C.F."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Paz C."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Lopez-Costa J.J."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Acquier A.B."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/author | "Mori Sequeiros Garcia M.M."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/pages | "2170-2181"xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/title | "ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin."xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/27061092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27061092 |
| http://purl.uniprot.org/citations/27061092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27061092 |
| http://purl.uniprot.org/uniprot/#_A6K5C4-mappedCitation-27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/#_G3V7Q4-mappedCitation-27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/#_Q63745-mappedCitation-27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/#_Q1EG89-mappedCitation-27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/#_Q66H76-mappedCitation-27061092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/A6K5C4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/G3V7Q4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27061092 |
| http://purl.uniprot.org/uniprot/Q66H76 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27061092 |