| http://purl.uniprot.org/citations/27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27063844 | http://www.w3.org/2000/01/rdf-schema#comment | "The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood. Here we show using the inositol polyphosphate 5'-phosphatase E (INPP5E) and the GTP-binding protein (Rheb) that cargo sorting depends on the affinity towards PDE6δ and the specificity of cargo release. High-affinity cargo is exclusively released by the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-ciliary homologue Arl2. Structures of PDE6δ/cargo complexes reveal the molecular basis of the sorting signal which depends on the residues at the -1 and -3 positions relative to farnesylated cysteine. Structure-guided mutation allows the generation of a low-affinity INPP5E mutant which loses exclusive ciliary localization. We postulate that the affinity to PDE6δ and the release by Arl2/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11366"xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/author | "Wittinghofer A."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/author | "Ismail S."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/author | "Zent E."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/author | "Fansa E.K."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/author | "Kosling S.K."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/pages | "11366"xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/title | "PDE6delta-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity."xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27063844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27063844 |
| http://purl.uniprot.org/citations/27063844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27063844 |
| http://purl.uniprot.org/uniprot/#_A0A494BAJ6-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_A2AIX0-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_F6X9A4-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_F6XC48-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_O43924-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_Q540E6-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_O55057-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_M0QWG6-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_M0QWR1-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |
| http://purl.uniprot.org/uniprot/#_Q3TZ34-mappedCitation-27063844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27063844 |