| http://purl.uniprot.org/citations/27065197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27065197 | http://www.w3.org/2000/01/rdf-schema#comment | "Elongation factor 4 (EF4) is a key quality-control factor in translation. Despite its high conservation throughout evolution, EF4 deletion in various organisms has not yielded a distinct phenotype. Here we report that genetic ablation of mitochondrial EF4 (mtEF4) in mice causes testis-specific dysfunction in oxidative phosphorylation, leading to male infertility. Deletion of mtEF4 accelerated mitochondrial translation at the cost of producing unstable proteins. Somatic tissues overcame this defect by activating mechanistic (mammalian) target of rapamycin (mTOR), thereby increasing rates of cytoplasmic translation to match rates of mitochondrial translation. However, in spermatogenic cells, the mTOR pathway was downregulated as part of the developmental program, and the resulting inability to compensate for accelerated mitochondrial translation caused cell-cycle arrest and apoptosis. We detected the same phenotype and molecular defects in germline-specific mtEF4-knockout mice. Thus, our study demonstrates cross-talk between mtEF4-dependent quality control in mitochondria and cytoplasmic mTOR signaling."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.3206"xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Han C."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/author | "Shangguan F."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/pages | "441-449"xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/title | "Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/27065197 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27065197 |
| http://purl.uniprot.org/citations/27065197 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27065197 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUM0-mappedCitation-27065197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27065197 |
| http://purl.uniprot.org/uniprot/#_E9Q7P8-mappedCitation-27065197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27065197 |
| http://purl.uniprot.org/uniprot/#_B7XGA6-mappedCitation-27065197 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27065197 |