| http://purl.uniprot.org/citations/27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27068360 | http://www.w3.org/2000/01/rdf-schema#comment | "Human embryonic stem cells (hESCs) are thought to be a promising resource for cell therapy, while it has to face the major problem of graft immunological rejection. Major histocompatibility complex (MHC) class I expressed on the cell surface is the major cause of graft rejection. Transporter associated with antigen presentation 1 (TAP1) and TAP-associated glycoprotein (TAPBP) play important roles in regulating MHC class I expression. In this study, we generated TAP1- and TAPBP-deficient hESC lines, respectively, using transcription activator-like effector nucleases technique. These cells showed deficient expression of MHC class I on the cell surface and reduced immunogenicity compared with wild types, but maintained normal pluripotency, karyotypes, and differentiation ability. Thus, our findings are instrumental in developing a universal cell resource with both pluripotency and hypo-immunogenicity for transplantation therapy in the future."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.org/dc/terms/identifier | "doi:10.1080/09168451.2016.1165601"xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Cui C."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Rao L."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/author | "Cui D."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/name | "Biosci Biotechnol Biochem"xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/pages | "1484-1491"xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/title | "Generating hESCs with reduced immunogenicity by disrupting TAP1 or TAPBP."xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://purl.uniprot.org/core/volume | "80"xsd:string |
| http://purl.uniprot.org/citations/27068360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27068360 |
| http://purl.uniprot.org/citations/27068360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27068360 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSV9-mappedCitation-27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068360 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MT98-mappedCitation-27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068360 |
| http://purl.uniprot.org/uniprot/#_A0A024RCT1-mappedCitation-27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068360 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4R8-mappedCitation-27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068360 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5A6-mappedCitation-27068360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068360 |