| http://purl.uniprot.org/citations/27068477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27068477 | http://www.w3.org/2000/01/rdf-schema#comment | "The conserved Bora protein is a Plk1 activator, essential for checkpoint recovery after DNA damage in human cells. Here, we show that Bora interacts with Cyclin B and is phosphorylated by Cyclin B/Cdk1 at several sites. The first 225 amino acids of Bora, which contain two Cyclin binding sites and three conserved phosphorylated residues, are sufficient to promote Plk1 phosphorylation by Aurora A in vitro. Mutating the Cyclin binding sites or the three conserved phosphorylation sites abrogates the ability of the N terminus of Bora to promote Plk1 activation. In human cells, Bora-carrying mutations of the three conserved phosphorylation sites cannot sustain mitotic entry after DNA damage. In C. elegans embryos, mutation of the three conserved phosphorylation sites in SPAT-1, the Bora ortholog, results in a severe mitotic entry delay. Our results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.03.049"xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Santamaria A."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Joly N."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Pintard L."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Schwager F."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Thomas Y."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Gotta M."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Martino L."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Panbianco C."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Tavernier N."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Van Hove L."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/author | "Cirillo L."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/pages | "510-518"xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/title | "Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells."xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/27068477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27068477 |
| http://purl.uniprot.org/citations/27068477 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27068477 |
| http://purl.uniprot.org/uniprot/#_A0A087WV86-mappedCitation-27068477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068477 |
| http://purl.uniprot.org/uniprot/#_B2R841-mappedCitation-27068477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068477 |
| http://purl.uniprot.org/uniprot/#_B4DUR2-mappedCitation-27068477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068477 |
| http://purl.uniprot.org/uniprot/#_B4E083-mappedCitation-27068477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27068477 |