| http://purl.uniprot.org/citations/27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27069112 | http://www.w3.org/2000/01/rdf-schema#comment | "Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report that B cell-intrinsic IFN-γ receptor (IFN-γR) and STAT1 signaling are required for Spt-GC and follicular T helper cell (Tfh cell) development. We further demonstrate that IFN-γR and STAT1 signaling control Spt-GC and Tfh cell formation by driving T-bet expression and IFN-γ production by B cells. Global or B cell-specific IFN-γR deficiency in autoimmune B6.Sle1b mice leads to significantly reduced Spt-GC and Tfh cell responses, resulting in diminished antinuclear Ab reactivity and IgG2c and IgG2b auto-Ab titers compared with B6.Sle1b mice. Additionally, we observed that the proliferation and differentiation of DNA-reactive B cells into a GC B cell phenotype require B cell-intrinsic IFN-γR signaling, suggesting that IFN-γR signaling regulates GC B cell tolerance to nuclear self-antigens. The IFN-γR deficiency, however, does not affect GC, Tfh cell, or Ab responses against T cell-dependent foreign antigens, indicating that IFN-γR signaling regulates autoimmune, but not the foreign antigen-driven, GC and Tfh cell responses. Together, our data define a novel B cell-intrinsic IFN-γR signaling pathway specific to Spt-GC development and autoimmunity. This novel pathway can be targeted for future pharmacological intervention to treat systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20151722"xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Kitamura D."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Chodisetti S.B."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Domeier P.P."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Elias M.J."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Rahman Z.S."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Soni C."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Wong E.B."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Cooper T.K."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/author | "Schell S.L."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/pages | "715-732"xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/title | "IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/27069112 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27069112 |
| http://purl.uniprot.org/citations/27069112 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27069112 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-27069112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27069112 |