| http://purl.uniprot.org/citations/27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27070406 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come from examination of genetically modified mice where the obligatory NMDAR-subunit GluN1 (also known as NR1) has been deleted from PV interneurons by Cre-mediated knockout of the corresponding gene Grin1 (Grin1(ΔPV) mice). Notably, such PV-specific GluN1 ablation has been reported to blunt the induction of hyperlocomotion (a surrogate for psychosis) by pharmacological NMDAR blockade with the non-competitive antagonist MK-801. This suggests PV-NMDARs as the site of the psychosis-inducing action of MK-801. In contrast to this hypothesis, we show here that Grin1(ΔPV) mice are not protected against the effects of MK-801, but are in fact sensitized to many of them. Compared with control animals, Grin1(ΔPV)mice injected with MK-801 show increased stereotypy and pronounced catalepsy, which confound the locomotor readout. Furthermore, in Grin1(ΔPV)mice, MK-801 induced medial-prefrontal delta (4 Hz) oscillations, and impaired performance on tests of motor coordination, working memory and sucrose preference, even at lower doses than in wild-type controls. We also found that untreated Grin1(ΔPV)mice are largely normal across a wide range of cognitive functions, including attention, cognitive flexibility and various forms of short-term memory. Taken together these results argue against PV-specific NMDAR hypofunction as a key starting point of schizophrenia pathophysiology, but support a model where NMDAR hypofunction in multiple cell types contribute to the disease."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.org/dc/terms/identifier | "doi:10.1038/tp.2016.44"xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Sprengel R."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Katzel D."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Harrison P.J."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Kullmann D.M."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Nicholson E."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Masiulis S."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Bannerman D.M."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Barkus C."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Bygrave A.M."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/author | "Berkemann M."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/name | "Transl Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/pages | "e778"xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/title | "Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801."xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27070406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27070406 |
| http://purl.uniprot.org/citations/27070406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27070406 |
| http://purl.uniprot.org/uniprot/#_A2AI14-mappedCitation-27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27070406 |
| http://purl.uniprot.org/uniprot/#_A2AI16-mappedCitation-27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27070406 |
| http://purl.uniprot.org/uniprot/#_A2AI17-mappedCitation-27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27070406 |
| http://purl.uniprot.org/uniprot/#_A2AI19-mappedCitation-27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27070406 |
| http://purl.uniprot.org/uniprot/#_A2AI20-mappedCitation-27070406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27070406 |