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http://purl.uniprot.org/citations/27072247http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27072247http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Not all the patients harboring epidermal growth factor receptor (EGFR) mutations have a clinical response after the treatment of EGFR-tyrosine kinase inhibitor (TKI). The purpose of the present study was to find whether the baseline carcinoembryonic antigen (CEA) levels were associated with the efficacy of EGFR-TKI in patients harboring EGFR mutations.

Materials and methods

Clinical features, serum tumor marker levels, and survival time were analyzed, retrospectively, in 200 non-small cell lung cancer (NSCLC) patients harboring EGFR mutations treated with EGFR-TKI.

Results

The total objective response rate (ORR) is 44.0% and disease control rate is 84.5%. The disease control rate in the patients with high CEA levels was significantly higher than that with low CEA levels (88.3 vs 74.5%, P = 0.029). There was no significant difference in progression-free survival (PFS) between high (≥5 ng/ml) and normal CEA groups (< ng/ml; 12.0 vs 8.3m, and P = 0.055). The PFS in patients with higher CEA levels (≥ 20 ng/ml) was longer than in patients with lower CEA levels (< ng/ml; 12.8 vs 8.7m, P = 0.016). Multivariate analysis shows that high CEA level (> ng/ml) were independent predictive factors for PFS (HR = 1.412, 93% CI: 1.042-1.913, P = 0.026).

Conclusions

Baseline serum CEA levels can serve as predictive factors for the treatment of EGFR-TKI in NSCLC patients harboring EGFR mutations."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.org/dc/terms/identifier"doi:10.4103/0973-1482.153666"xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Rong L."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Song H."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Bo J."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Yuqing L."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Baohui H."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Xueyan Z."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/author"Yanwei Z."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/name"J Cancer Res Ther"xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/pages"254-258"xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/title"Serum carcinoembryonic antigen levels predicts the efficacy of EGFR-TKI in non-small cell lung cancer harboring EGFR mutations."xsd:string
http://purl.uniprot.org/citations/27072247http://purl.uniprot.org/core/volume"12"xsd:string
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