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http://purl.uniprot.org/citations/27072340http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27072340http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

Atherosclerosis is both a chronic inflammatory disease and a lipid metabolism disorder. C/EBPβ is well documented for its role in the development of hematopoietic cells and integration of lipid metabolism. However, C/EBPβ's role in atherosclerotic progression has not been examined. We assessed the impact of hematopoietic CEBPβ deletion in ApoE(-/-) mice on hyperlipidemia, inflammatory responses and lesion formation in the aorta.

Methods and results

ApoE(-/-) mice were reconstituted with bone marrow cells derived from either WT or C/EBPβ(-/-) mice and placed on low fat or high fat/high cholesterol diet for 11 weeks. Hematopoietic C/EBPβ deletion in ApoE(-/-) mice reduced blood and hepatic lipids and gene expression of hepatic stearoyl CoA desaturase 1 and fatty acid synthase while expression of ATP binding cassette transporter G1, cholesterol 7-alpha-hydroxylase, and liver X receptor alpha genes were significantly increased. ApoE(-/-) mice reconstituted with C/EBPβ(-/-) bone marrow cells also significantly reduced blood cytokine levels and reduced lesion area in aortic sinuses compared with ApoE(-/-) mice reconstituted with WT bone marrow cells. Silencing of C/EBPβ in RAW264.7 macrophage cells prevented oxLDL-mediated foam cell formation and inflammatory cytokine secretion in conditioned medium.

Conclusion

C/EBPβ in hematopoietic cells is crucial to regulate diet-induced inflammation, hyperlipidemia and atherosclerosis development."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.org/dc/terms/identifier"doi:10.1016/j.atherosclerosis.2016.03.040"xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Miyazaki M."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Wang S."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Sun M."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Rahman S.M."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Moustaid-Moussa N."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Choudhury M."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Janssen R.C."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Miyazaki-Anzai S."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Friedman J.E."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"de la Houssaye B.A."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/author"Baquero K.C."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/name"Atherosclerosis"xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/pages"172-179"xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/title"C/EBPbeta in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis."xsd:string
http://purl.uniprot.org/citations/27072340http://purl.uniprot.org/core/volume"250"xsd:string
http://purl.uniprot.org/citations/27072340http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27072340
http://purl.uniprot.org/citations/27072340http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27072340
http://purl.uniprot.org/uniprot/#_P28033-mappedCitation-27072340http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27072340
http://purl.uniprot.org/uniprot/#_O70192-mappedCitation-27072340http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27072340
http://purl.uniprot.org/uniprot/#_Q3UPN9-mappedCitation-27072340http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27072340
http://purl.uniprot.org/uniprot/#_Q6LD68-mappedCitation-27072340http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27072340
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