| http://purl.uniprot.org/citations/27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27074664 | http://www.w3.org/2000/01/rdf-schema#comment | "G protein gated inward rectifier potassium (GIRK) channels are gated by direct binding of G protein beta-gamma subunits (Gβγ), signaling lipids, and intracellular Na(+). In cardiac pacemaker cells, hetero-tetramer GIRK1/4 channels and homo-tetramer GIRK4 channels play a central role in parasympathetic slowing of heart rate. It is known that the Na(+) binding site of the GIRK1 subunit is defective, but the functional difference between GIRK1/4 hetero-tetramers and GIRK4 homo-tetramers remains unclear. Here, using purified proteins and the lipid bilayer system, we characterize Gβγ and Na(+) regulation of GIRK1/4 hetero-tetramers and GIRK4 homo-tetramers. We find in GIRK4 homo-tetramers that Na(+) binding increases Gβγ affinity and thereby increases the GIRK4 responsiveness to G protein stimulation. GIRK1/4 hetero-tetramers are not activated by Na(+), but rather are in a permanent state of high responsiveness to Gβγ, suggesting that the GIRK1 subunit functions like a GIRK4 subunit with Na(+) permanently bound."xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.15750"xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/author | "MacKinnon R."xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/author | "Touhara K.K."xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/pages | "e15750"xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/title | "The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers."xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27074664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27074664 |
| http://purl.uniprot.org/citations/27074664 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27074664 |
| http://purl.uniprot.org/uniprot/#_A0A5J6E2W8-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_B4DF44-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_D2X9V0-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_D2XBF0-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_H9A8K9-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_H9A8L0-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_H7CGH0-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_Q4QRJ2-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_Q53R59-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_P48544-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/#_P48549-mappedCitation-27074664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27074664 |
| http://purl.uniprot.org/uniprot/B4DF44 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27074664 |