| http://purl.uniprot.org/citations/27077886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27077886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27077886 | http://www.w3.org/2000/01/rdf-schema#comment | "PnTx4(6-1), henceforth renamed δ-Ctenitoxin-Pn1a (δ-CNTX-Pn1a), a peptide from Phoneutria nigriventer spider venom, initially described as an insect toxin, binds to site 3 of sodium channels in nerve cord synaptosomes and slows down sodium current inactivation in isolated axons in cockroaches (Periplaneta americana). δ-CNTX-Pn1a does not cause any apparent toxicity to mice, when intracerebroventricularly injected (30 μg). In this study, we evaluated the antinociceptive effect of δ-CNTX-Pn1a in three animal pain models and investigated its mechanism of action in acute pain. In the inflammatory pain model, induced by carrageenan, δ-CNTX-Pn1a restored the nociceptive threshold of rats, when intraplantarly injected, 2 h and 30 min after carrageenan administration. Concerning the neuropathic pain model, δ-CNTX-Pn1a, when intrathecally administered, reversed the hyperalgesia evoked by sciatic nerve constriction. In the acute pain model, induced by prostaglandin E₂, intrathecal administration of δ-CNTX-Pn1a caused a dose-dependent antinociceptive effect. Using antagonists of the receptors, we showed that the antinociceptive effect of δ-CNTX-Pn1a involves both the cannabinoid system, through CB₁ receptors, and the opioid system, through μ and δ receptors. Our data show, for the first time, that δ-Ctenitoxin-Pn1a is able to induce antinociception in inflammatory, neuropathic and acute pain models."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.org/dc/terms/identifier | "doi:10.3390/toxins8040106"xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.org/dc/terms/identifier | "doi:10.3390/toxins8040106"xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Cordeiro M.N."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Cordeiro M.N."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Figueiredo S.G."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Figueiredo S.G."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Borges M.H."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Borges M.H."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "de Lima M.E."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "de Lima M.E."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Pimenta A.M."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Pimenta A.M."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Ferreira R.C."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Ferreira R.C."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Duarte I.D."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Duarte I.D."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Emerich B.L."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/author | "Emerich B.L."xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/name | "Toxins"xsd:string |
| http://purl.uniprot.org/citations/27077886 | http://purl.uniprot.org/core/name | "Toxins"xsd:string |