| http://purl.uniprot.org/citations/27077953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27077953 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurons of the cerebellar nuclei (CbN) transmit cerebellar signals to premotor areas. The cerebellum expresses several autism-linked genes, including GABRB3, which encodes GABAA receptor β3 subunits and is among the maternal alleles deleted in Angelman syndrome. We tested how this Gabrb3 m-/p+ mutation affects CbN physiology in mice, separating responses of males and females. Wild-type mice showed sex differences in synaptic excitation, inhibition, and intrinsic properties. Relative to females, CbN cells of males had smaller synaptically evoked mGluR1/5-dependent currents, slower Purkinje-mediated IPSCs, and lower spontaneous firing rates, but rotarod performances were indistinguishable. In mutant CbN cells, IPSC kinetics were unchanged, but mutant males, unlike females, showed enlarged mGluR1/5 responses and accelerated spontaneous firing. These changes appear compensatory, since mutant males but not females performed indistinguishably from wild-type siblings on the rotarod task. Thus, sex differences in cerebellar physiology produce similar behavioral output, but provide distinct baselines for responses to mutations."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07596"xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/author | "Mercer A.A."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/author | "Raman I.M."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/author | "Woolley C.S."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/author | "Tabatadze N."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/author | "Palarz K.J."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/pages | "e07596"xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/title | "Sex differences in cerebellar synaptic transmission and sex-specific responses to autism-linked Gabrb3 mutations in mice."xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27077953 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27077953 |
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