http://purl.uniprot.org/citations/27079694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27079694 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsRound-cell sarcomas lacking specific translocations represent a diagnostic challenge. The aim of this study was to describe seven cases of CIC-DUX4 fusion-positive sarcomas, including the first reported example arising primarily in bone.Methods and resultsPatients ranged in age from 15 years to 44 years (median: 33 years). Six cases arose from the soft tissues, and one from the iliac bone. Morphologically, all cases showed an undifferentiated round-cell population with greater atypia and pleomorphism than Ewing sarcoma. Immunohistochemically, all tumours showed focal and weak positivity for CD99, and five of seven showed nuclear and/or cytoplasmic positivity for Wilms tumour 1. Five patients had lung metastases at presentation. All patients received chemotherapy according to Ewing sarcoma protocols. All but one patient (the one with a bone tumour) died of disease after a mean of 14.5 months from the diagnosis (range: 8-20 months).ConclusionsOur series confirms that CIC-DUX4 fusion-positive sarcomas are aggressive tumours with an adverse prognosis, and with clinical, histological and genetic differences from Ewing sarcoma. The best therapeutic approach needs to be investigated."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.org/dc/terms/identifier | "doi:10.1111/his.12985"xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Benini S."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Ferrari S."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Dei Tos A.P."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Gambarotti M."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Picci P."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Cocchi S."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Gamberi G."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Donati D."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Righi A."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Palmerini E."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Sbaraglia M."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/author | "Vanel D."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/name | "Histopathology"xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/pages | "624-634"xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/title | "CIC-DUX4 fusion-positive round-cell sarcomas of soft tissue and bone: a single-institution morphological and molecular analysis of seven cases."xsd:string |
http://purl.uniprot.org/citations/27079694 | http://purl.uniprot.org/core/volume | "69"xsd:string |
http://purl.uniprot.org/citations/27079694 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27079694 |
http://purl.uniprot.org/citations/27079694 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27079694 |
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http://purl.uniprot.org/uniprot/#_A0A2H4V0R9-mappedCitation-27079694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27079694 |