| http://purl.uniprot.org/citations/27084119 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27084119 | http://www.w3.org/2000/01/rdf-schema#comment | "Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice. DSS-induced colitis was associated with altered enteric viral abundance and composition. When wild-type mice were reconstituted with Toll-like receptor 3 (TLR3) or TLR7 agonists or inactivated rotavirus, colitis symptoms were significantly ameliorated. Mice deficient in both TLR3 and TLR7 were more susceptible to DSS-induced experimental colitis. In humans, combined TLR3 and TLR7 genetic variations significantly influenced the severity of ulcerative colitis. Plasmacytoid dendritic cells isolated from inflamed mouse colon produced interferon-β in a TLR3 and TLR7-dependent manner. These results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.03.009"xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Bae J.W."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Choi S.S."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Chang S.Y."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Ko H.J."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Shin S.H."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Kim M.S."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Kweon M.N."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Seo S.U."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/author | "Cheon J.H."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/pages | "889-900"xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/title | "Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-beta Production."xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/27084119 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27084119 |
| http://purl.uniprot.org/citations/27084119 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27084119 |