| http://purl.uniprot.org/citations/27085459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27085459 | http://www.w3.org/2000/01/rdf-schema#comment | "The androgen receptor (AR) plays a critical role in the initiation and progression of prostate cancer (PCa), and thus its regulation is an important tool in PCa therapy. Here, we report that CDK2-associated cullin 1 (CACUL1) directly associates with AR and suppresses AR transcriptional activity. In addition, CACUL1 represses histone demethylase LSD1-mediated AR transactivation by competing with LSD1 for AR binding. Depletion of CACUL1 enhances the LSD1 occupancy of the AR-target promoter, accompanied by decreased accumulation of H3K9me2, a repressive transcriptional marker. CACUL1 and LSD1 oppositely regulate CDX-induced cell death in AR-positive LNCaP and metastatic castrate-resistant LNCaP-LN3 cells. These data suggest that CACUL1 impairs LSD1-mediated activation of AR, thereby implicating it as a potential antitumor target in PCa."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2016.04.019"xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/author | "Choi H."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/author | "Kim E.J."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/author | "Um S.J."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/pages | "360-366"xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/title | "CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/27085459 | http://purl.uniprot.org/core/volume | "376"xsd:string |
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