| http://purl.uniprot.org/citations/27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27086966 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress is a key pathological feature of Parkinson's disease (PD). Glutathione S-transferase pi (GSTP) is a neuroprotective antioxidant enzyme regulated at the transcriptional level by the antioxidant master regulator nuclear factor-erythroid 2-related factor 2 (Nrf2). Here, we show for the first time that upon MPTP-induced oxidative stress, GSTP potentiates S-glutathionylation of Kelch-like ECH-associated protein 1 (Keap1), an endogenous repressor of Nrf2, in vivo. S-glutathionylation of Keap1 leads to Nrf2 activation and subsequently increases expression of GSTP. This positive feedback regulatory loop represents a novel mechanism by which GSTP elicits antioxidant protection in the brain."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12177"xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Rodrigues E."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Marques C."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Gama M.J."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Castro-Caldas M."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Guedes R.C."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "van Horssen J."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/author | "Carvalho A.N."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/pages | "1455-1466"xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/title | "S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection."xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://purl.uniprot.org/core/volume | "590"xsd:string |
| http://purl.uniprot.org/citations/27086966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27086966 |
| http://purl.uniprot.org/citations/27086966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27086966 |
| http://purl.uniprot.org/uniprot/#_E2I973-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
| http://purl.uniprot.org/uniprot/#_A0A0M5MRY8-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
| http://purl.uniprot.org/uniprot/#_A0A0M4UT83-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
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| http://purl.uniprot.org/uniprot/#_A0A494B908-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
| http://purl.uniprot.org/uniprot/#_B7ZA33-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
| http://purl.uniprot.org/uniprot/#_A0A2P1FDF0-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TN14-mappedCitation-27086966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27086966 |