| http://purl.uniprot.org/citations/27093083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27093083 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromeres mediate the conserved process of chromosome segregation, yet centromeric DNA and the centromeric histone, CENP-A, are rapidly evolving. The rapid evolution of Drosophila CENP-A loop 1 (L1) is thought to modulate the DNA-binding preferences of CENP-A to counteract centromere drive, the preferential transmission of chromosomes with expanded centromeric satellites. Consistent with this model, CENP-A from Drosophila bipectinata (bip) cannot localize to Drosophila melanogaster (mel) centromeres. We show that this result is due to the inability of the mel CENP-A chaperone, CAL1, to deposit bip CENP-A into chromatin. Co-expression of bip CENP-A and bip CAL1 in mel cells restores centromeric localization, and similar findings apply to other Drosophila species. We identify two co-evolving regions, CENP-A L1 and the CAL1 N terminus, as critical for lineage-specific CENP-A incorporation. Collectively, our data show that the rapid evolution of L1 modulates CAL1-mediated CENP-A assembly, suggesting an alternative mechanism for the suppression of centromere drive."xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2016.03.021"xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/author | "Mellone B.G."xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/author | "Rosin L."xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/pages | "136-147"xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/title | "Co-evolving CENP-A and CAL1 Domains Mediate Centromeric CENP-A Deposition across Drosophila Species."xsd:string |
| http://purl.uniprot.org/citations/27093083 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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