| http://purl.uniprot.org/citations/27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27093086 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria play central roles in buffering intracellular Ca²⁺ transients. While basal mitochondrial Ca²⁺ (Ca²⁺ mito) is needed to maintain organellar physiology, Ca²⁺ mito overload can lead to cell death. How Ca²⁺ mito homeostasis is regulated is not well understood. Here we show that Miro, a known component of the mitochondrial transport machinery, regulates Drosophila neural stem cell (NSC) development through Ca²⁺ mito homeostasis control, independent of its role in mitochondrial transport. Miro interacts with Ca²⁺ transporters at the ER-mitochondria contact site (ERMCS). Its inactivation causes Ca²⁺ mito depletion and metabolic impairment, whereas its overexpression results in Ca²⁺ mito overload, mitochondrial morphology change, and apoptotic response. Both conditions impaired NSC lineage progression. Ca²⁺ mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro, which positively regulates Miro localization to, and the integrity of, ERMCS. Our results elucidate a regulatory mechanism underlying Ca²⁺ mito homeostasis and how its dysregulation may affect NSC metabolism/development and contribute to disease."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2016.03.023"xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Hong S.H."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Lee D.Y."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/author | "Huh S."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/pages | "174-189"xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/title | "Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development."xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/27093086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27093086 |
| http://purl.uniprot.org/citations/27093086 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFG2-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHX7-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7V5-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGW0-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J3Z9-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG56-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGJ5-mappedCitation-27093086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27093086 |