DESCRIBE <http://purl.uniprot.org/citations/27094728>

Subject	Predicate	Object
http://purl.uniprot.org/citations/27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27094728	http://www.w3.org/2000/01/rdf-schema#comment	" Problem CpG oligodeoxynucleotides (ODNs) can induce immunological changes in non-obese diabetic (NOD) mice and increase embryo loss, but little is known about the mechanism. This study aimed to determine the role of adiponectin in CpG ODN-induced pregnancy failure. Method of study Oligodeoxynucleotide 1826 was intraperitoneally injected to NOD mice, and ODN 2216, ODN 2006, and ODN 2395 were used to stimulate human trophoblast cell lines to investigate adiponectin expression patterns and its possible effects on trophoblast function. Results CpG ODNs downregulated adiponectin via the cJun N-terminal kinase signaling pathway and led to increased embryo loss (from 6.9 to 33.3%). ODN 2006 impaired human trophoblast cell migration, which was successfully rescued by adiponectin treatment. Conclusion CpG ODNs decreased placental adiponectin expression in NOD mice and impaired human trophoblast function and was associated with increased embryo loss. Adiponectin may therefore play an important protective role in the prevention of bacteria-induced pregnancy failure."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.org/dc/terms/identifier	"doi:10.1111/aji.12515"xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Lin Y."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Wu F."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Ma X.L."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Liu X.R."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Tian F.J."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/author	"Qin C.M."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/date	"2016"xsd:gYear
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/name	"Am J Reprod Immunol"xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/pages	"38-49"xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/title	"CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non-Obese Diabetic Mice."xsd:string
http://purl.uniprot.org/citations/27094728	http://purl.uniprot.org/core/volume	"76"xsd:string
http://purl.uniprot.org/citations/27094728	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/27094728
http://purl.uniprot.org/citations/27094728	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/27094728
http://purl.uniprot.org/uniprot/#_A0A3B0J1H7-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/#_A8K660-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/#_B2R773-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/#_Q15848-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/#_Q60994-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/#_Q8BRW2-mappedCitation-27094728	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/Q60994	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/B2R773	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/27094728
http://purl.uniprot.org/uniprot/Q8BRW2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/27094728