| http://purl.uniprot.org/citations/27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27094744 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. The identification of cancer cell internalizing antigens for drug targeting to the hypoxic tumour niche remains a challenge of high clinical relevance. Here we show that hypoxia down-regulates the surface proteome at the global level and, more specifically, membrane proteome internalization. We find that hypoxic down-regulation of constitutive endocytosis is HIF-independent, and involves caveolin-1-mediated inhibition of dynamin-dependent, membrane raft endocytosis. Caveolin-1 overexpression inhibits protein internalization, suggesting a general negative regulatory role of caveolin-1 in endocytosis. In contrast to this global inhibitory effect, we identify several proteins that can override caveolin-1 negative regulation, exhibiting increased internalization at hypoxia. We demonstrate antibody-mediated cytotoxin delivery and killing specifically of hypoxic cells through one of these proteins, carbonic anhydrase IX. Our data reveal that caveolin-1 modulates cell-surface proteome turnover at hypoxia with potential implications for specific targeting of the hypoxic tumour microenvironment."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms11371"xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Welinder C."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Lindqvist E."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Belting M."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Marko-Varga G."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Christianson H.C."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Bourseau-Guilmain E."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Lidfeldt J."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Menard J.A."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Cerezo Magana M."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/author | "Indira Chandran V."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/pages | "11371"xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/title | "Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells."xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27094744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27094744 |
| http://purl.uniprot.org/citations/27094744 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27094744 |
| http://purl.uniprot.org/uniprot/#_A9XTE5-mappedCitation-27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27094744 |
| http://purl.uniprot.org/uniprot/#_B3KU80-mappedCitation-27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27094744 |
| http://purl.uniprot.org/uniprot/#_B4DK06-mappedCitation-27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27094744 |
| http://purl.uniprot.org/uniprot/#_B4DHH5-mappedCitation-27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27094744 |
| http://purl.uniprot.org/uniprot/#_B7ZAC0-mappedCitation-27094744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27094744 |