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http://purl.uniprot.org/citations/27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27096699http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The importance of HLA-B*15:02 genotyping to avoid carbamazepine induced SJS/TEN and molecular modeling to predict the role of HLA-B*15:0 and AEDs induced SJS/TEN are investigated.

Methods

DNA was extracted from eighty-six patients. The patients were genotyped by AS-PCR. Computational modeling of the HLA-B*15:02 followed by docking studies were performed to screen 26 AEDs that may induce ADR among HLA-B*15:02 carriers.

Results

Odd ratio for CBZ induced SJS/TEN and HLA-B*15:02 was 609.0 (95% CI: 23-15873; p=0.0002). Molecular modeling studies showed that acetazolamide, ethosuxiamide, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone and sodium-valproate may induce ADR in HLA-B*15:02 carriers alike CBZ. Conclusion. We confirmed HLA-B*15:02 as a predictor of SJS/TEN and recommend pre-screening. Computational prediction of DIHR is useful in personalized medicine."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.org/dc/terms/identifier"doi:10.18433/j38g7x"xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Selvaraj M."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Salleh M.Z."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Teh L.K."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Ismail M.I."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Law W.C."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Ali P.S."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Puvanarajah S."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Bannur Z."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Rafia H."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/author"Sapuan S."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/date"2016"xsd:gYear
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/name"J Pharm Pharm Sci"xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/pages"147-160"xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/title"Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02."xsd:string
http://purl.uniprot.org/citations/27096699http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/27096699http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/27096699
http://purl.uniprot.org/citations/27096699http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/27096699
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27096699
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27096699
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27096699
http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27096699
http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-27096699http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/27096699
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