| http://purl.uniprot.org/citations/27098909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27098909 | http://www.w3.org/2000/01/rdf-schema#comment | "The extent to which selection and demography impact patterns of genetic diversity in natural populations of Drosophila melanogaster is yet to be fully understood. We previously observed that linkage disequilibrium (LD) at scales of ∼10 kb in the Drosophila Genetic Reference Panel (DGRP), consisting of 145 inbred strains from Raleigh, North Carolina, measured both between pairs of sites and as haplotype homozygosity, is elevated above neutral demographic expectations. We also demonstrated that signatures of strong and recent soft sweeps are abundant. However, the extent to which these patterns are specific to this derived and admixed population is unknown. It is also unclear whether these patterns are a consequence of the extensive inbreeding performed to generate the DGRP data. Here we analyze LD statistics in a sample of >100 fully-sequenced strains from Zambia; an ancestral population to the Raleigh population that has experienced little to no admixture and was generated by sequencing haploid embryos rather than inbred strains. We find an elevation in long-range LD and haplotype homozygosity compared to neutral expectations in the Zambian sample, thus showing the elevation in LD is not specific to the DGRP data set. This elevation in LD and haplotype structure remains even after controlling for possible confounders including genomic inversions, admixture, population substructure, close relatedness of individual strains, and recombination rate variation. Furthermore, signatures of partial soft sweeps similar to those found in the DGRP as well as partial hard sweeps are common in Zambia. These results suggest that while the selective forces and sources of adaptive mutations may differ in Zambia and Raleigh, elevated long-range LD and signatures of soft sweeps are generic in D. melanogaster."xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.115.184002"xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/author | "Petrov D.A."xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/author | "Garud N.R."xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/pages | "863-880"xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/title | "Elevated Linkage Disequilibrium and Signatures of Soft Sweeps Are Common in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/27098909 | http://purl.uniprot.org/core/volume | "203"xsd:string |
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